Natural deduction systems for classical, intuitionistic and modal logics were deeply investigated by Prawitz [D. Prawitz, Natural Deduction: A Proof-theoretical Study, in: Stockholm Studies in Philosophy, vol. 3, Almqvist and Wiksell, Stockholm, 1965. Reprinted at: Dover Publications, Dover Books on Mathematics, 2006] from a proof-theoretical perspective. Prawitz proved weak normalization for classical logic only for a language without logical or, there exists and with a restricted application of reduction ad absurdum. Reduction steps related to logical or, there exists and classical (...) negation bring about many problems solved only rather recently. For classical S5 modal logic, Prawitz defined a normalizable system, but for a language without logical or, there exists, ◊ and, for a propositional language without ◊, Medeiros [M.da P.N. Medeiros, A new S4 classical modal logic in natural deduction, Journal of Symbolic Logic 71 799–809] presented a normalizable system for classical S4. We can mention many cut-free Gentzen systems for S4, S5 and K45/K45D, some normalizable natural deduction systems for intuitionistic modal logics and one more for full classical S4, but not for full classical S5. Here our focus is on the definition of a classical and normalizable natural deduction system for S5, taking not only □ and ◊ as primitive symbols, but also all connectives and quantifiers, including classical negation, disjunction and the existential quantifier. The normalization procedure is based on the strategy proposed by Massi [C.D.B. Massi, Provas de normalizaçaõ para a lógica clássica, Ph.D. Thesis, Departamento de Filosofia, UNICAMP, Campinas, 1990] and Pereira and Massi [L.C. Pereira, C.D.B. Massi, Normalização para a lógica clássica, in: O que nos faz pensar, Cadernos de Filosofia da PUC-RJ, vol. 2, 1990, pp. 49–53] for first-order classical logic to cope with the combined use of classical negation, disjunction and the existential quantifier. Here we extend such results to deal with □ and ◊ too. The elimination rule for ◊ uses the notions of connection and of essentially modal formulas already proposed by Prawitz for the introduction of □. Beyond weak normalization, we also prove the subformula property for full S5. (shrink)

Resumo: Este artigo mostra a abordagem hermenêutica realizada por Martin Heidegger dos conceitos de natureza e vida a partir da ontologia fundamental. Em Ser e Tempo, Heidegger elabora as condições hermenêuticas para que se possa apreender ontologicamente a vida através do que ele chama de interpretação privativa da vida. O desenvolvimento sistemático do sentido de ser da vida é apresentado por Heidegger na preleção Os conceitos fundamentais da metafísica : mundo, finitude, solidão, de 1929/1930. Nela, para apresentar o fenômeno da (...) vida, Heidegger parte da tese central de que todo vivente é organismo, de modo a desenvolver uma investigação ontológica em conjunto com pesquisas biológicas e zoológicas. Por conseguinte, após a explicitação dos modos de encontro com a natureza, será evidenciado como a natureza em sentido originário mostra-se a partir de um retraimento na abertura de mundo do ser-aí em sua relação com os organismos vivos. Palavras-chave: Heidegger; ontologia; hermenêutica da natureza; vida; mundo.: This article shows the hermeneutical approach performed by Martin Heidegger to the concepts of nature and life from the fundamental ontology. In Being and Time, Heidegger elaborates the hermeneutical conditions so that we can apprehend ontologically life through what he calls the private interpretation of life. The systematic development of the sense of being of life is presented by Heidegger in the lecture course The Fundamental Concepts of Metaphysics: World, Finitude, Solitude, of 1929/1930. In this lecture, to present the phenomenon of life Heidegger uses the central thesis that every living being is organism in order to develop an ontological investigation in conjunction with biological and zoological research. Therefore, after the explanation of the ways of meeting with nature, will be shown as nature in the original sense shows itself from a withdrawal in the world opening of the being-there in its relationship with living organisms. Keywords: Heidegger; ontology; hermeneutic of nature; life; world. (shrink)

This article evaluated the effects of an interpersonal skills program based on artistic expressions to reduce intimate partner violence in college students. The research was of explanatory type, quasi-experimental design and used the Dating Abuse questionnaire (adapted by Osorio, 2014), the Interpersonal Skills questionnaire with reliability of 0.81 having as results in the entry test in terms of violence a mean of 88. 16 and after the program was applied it decreased to 81.2, in interpersonal skills the mean of 46.6 (...) increased to 53.3 with large effect size according to Cohen's d 7.889 CI95% (6.246-9.532), statistically significant differences were found in terms of violence. (shrink)

Online supplement, "Mulsow: Additions to Notes drawn from the 2002 edition of Moderne aus dem Untergrund" full versions of nearly 300 notes that were truncated in the print edition. Hosted on H. C. Erik Midelfort's website. Martin Mulsow's seismic reinterpretation of the origins of the Enlightenment in Germany won awards and renown in its original German edition, and now H. C. Erik Midelfort's translation makes this sensational book available to English-speaking readers. In Enlightenment Underground, Mulsow shows that even in the (...) late seventeenth century some thinkers in Germany ventured to express extremely dangerous ideas, but did so as part of a secret underground. Scouring manuscript collections across northern Europe, Mulsow studied the writings of countless hitherto unknown radical jurists, theologians, historians, and dissident students who pushed for the secularization of legal, political, social, and religious knowledge. Often their works circulated in manuscript, anonymously, or as clandestinely published books. Working as a philosophical microhistorian, Mulsow has discovered the identities of several covert radicals and linked them to circles of young German scholars, many of whom were connected with the vibrant radical cultures of the Netherlands, England, and Denmark. The author reveals how radical ideas and contributions to intellectual doubt came from Socinians and Jews, church historians and biblical scholars, political theorists, and unemployed university students. He shows that misreadings of humorous or ironic works sometimes gave rise to unintended skeptical thoughts or corrosively political interpretations of Christianity. This landmark book overturns stereotypical views of the early Enlightenment in Germany as cautious, conservative, and moderate, and replaces them with a new portrait that reveals a movement far more radical, unintended, and puzzling than previously suspected. (shrink)

The humanitarian sector continually faces organizational and operational challenges to respond to the needs of populations affected by war, disaster, displacement, and health emergencies. With the goal of improving the effectiveness and efficiency of response efforts, humanitarian innovation initiatives seek to develop, test, and scale a variety of novel and adapted practices, products, and systems. The innovation process raises important ethical considerations, such as appropriately engaging crisis-affected populations in defining problems and identifying potential solutions, mitigating risks, ensuring accountability, sharing benefits (...) fairly, and managing expectations. This paper aims to contribute to knowledge and practice regarding humanitarian innovation ethics and presents two components related to a value-sensitive approach to humanitarian innovation. First is a mapping of how ethical concepts are mobilized in values statements that have been produced by a diverse set of organizations involved in humanitarian innovation. Analyzing these documents, we identified six primary values (do-no-harm, autonomy, justice, accountability, sustainability, and inclusivity) around which we grouped 12 secondary values and 10 associated concepts. Second are two proposed activities that teams engaged in humanitarian innovation can employ to foreground values as they develop and refine their project’s design, and to anticipate and plan for challenges in enacting these values across the phases of their project. A deliberate and tangible approach to engaging with values within humanitarian innovation design can help to ground humanitarian innovation in ethical commitments by increasing shared understanding amongst team members, promoting attentiveness to values across the stages of innovation, and fostering capacities to anticipate and respond to ethically challenging situations. (shrink)

Neste artigo abordo a questão da interpretação de Hegel acerca do conceito de apercepção pura transcendental em Kant. Como procuro mostrar, Hegel inicialmente faz uma análise positiva do argumento kantiano acerca da apercepção, concordando com Kant sobre a unidade e o caráter pensante e autorreferente do eu. Com efeito, para Hegel, Kant elabora uma compreensão muito importante sobre a natureza do conhecimento, ao afirmar que a unidade conceitual da autoconsciência constitui a unidade do objeto. Contudo, por outro lado, Hegel analisa (...) o argumento kantiano sob outra perspectiva, sustentando que Kant não desenvolve coerentemente a tese da unidade da apercepção pura e acaba por considerar a autoconsciência apenas do ponto de vista subjetivo, em uma relação externa com o objeto. Neste contexto, minha leitura é que Hegel incorpora em sua Lógica aquilo que ele concebe como um elemento especulativo no interior do argumento kantiano sobre a apercepção pura transcendental, transformando, assim, a compreensão kantiana sobre o eu penso em sua concepção lógico-especulativa sobre o conceito subjetivo. Nestes termos, dialogo com a interpretação de Robert Pippin em Hegel ́s Idealism, discordando da afirmação do autor, segundo a qual, a concepção hegeliana sobre o conceito na Ciência da Lógica consiste em uma continuidade da concepção kantiana sobre a apercepção pura transcendental. (shrink)

The article offers an account of the author's participation in secret filming in three small residential care homes for older people. The author gained access to the homes as a resident and made video-recordings that were used as part of a television documentary in 1994 that exposed the poor practice and lack of regulation in these types of homes in England at that time. The author discusses her motivations for taking on this undercover role, and some of the unexpected ethical (...) challenges she faced when considering the impact of the exposure of these homes for the residents, their families, the owners and the staff. (shrink)

The aging of the population presents modern Western society with a variety of different challenges, especially in the areas of health and medicine. On the one hand, there is the demand of the elderly patients to receive medical treatments that are supposed to improve or preserve the existing quality of life and to prevent the extension of a life without quality, with suffering and pain. On the other hand, aging is accompanied by the appearance and exacerbation of chronic illnesses, reduces (...) the treatment benefits of medical activities and increases the risks of irreversible physical dependence. Furthermore, the lack of consensus among the physicians regarding the willingness of treatment and the proper timing of the treatment of the elderly – pose questions about the quality of the treatment for the elderly. Thus, in the opinion of different care-providers and in comparison to other age groups in modern Western society, the elderly do not enjoy the treatment advantages of medical activities proven in the treatment of other age groups in society. (shrink)

Mediante el análisis de las relaciones de parentalidad en Tiempo de vida, El cuerpo en que nací y ¿Por qué ser feliz cuando puedes ser normal?, de Marcos Giralt Torrente, Guadalupe Nettel y Jeanette Winterson respectivamente, se expondrá cómo la literatura autoficcional, en tanto ejercicio artístico, adquiere también una función capaz de reconfigurar la realidad patriarcal y, así, contribuir a desmontar un esencialismo estructural. La incipiente actualidad de estos autores constituye también una propuesta de escrituras descentralizadas o marginales leídas desde (...) el Sur: literatura de los hijos parentales, literatura de mujeres y literatura con perspectiva homoerótica. Para ello, partiendo de una metodología comparatista literaria desde epistemologías de género del Sur, se ejemplifican y visibilizan costumbres heteronormativas de un contexto capitalista que deteriora la identidad de un yo relacional, en un sistema político, social y económico jerárquico y represor. Se realiza un análisis de personajes que rompen con la idea estereotípica de relaciones familiares, permitiendo así esbozar nuevas concepciones de identidad a partir de una serie de autores clave en el tema de la ruptura heteronormativa. La presente es una apuesta en favor de la literatura como un arte que, además de brindar goce estético, puede constituir una poderosa vía de concientización y transformación epistémica –es decir, del desplazamiento del deseo–, a partir de la experiencia humana, en general y, en particular, a través de la experiencialidad ficcional (cargada de tintes autobiográficos) de un yo-relacional que da cuenta de vicisitudes relacionadas con el mandato de masculinidad, entendido como “la obligación de dominio que recae sobre los hombres” de algunos personajes literarios. Tal obligación [y la] “investidura [social que se impone] a quienes cargan un cuerpo masculino” son cuestionadas e incluso transformadas en los textos seleccionados que, cuando son explorados en el marco de la educación superior, pueden contribuir a la educación inclusiva en el Sur global. (shrink)

ResumoO objetivo deste artigo é produzir uma reflexão crítica sobre a produção de Gilberto Freyre, mais verticalizada em dois aspectos. Em primeiro lugar, buscar-se-á entender a seleção feita por esse antropólogo de uma certa mestiçagem e adaptação cultural, símbolos da singularidade brasileira. Em segundo lugar, procura-se entender de que maneira esse tipo de interpretação desloca a análise de fenômenos mais sociais e econômicos, investindo profundamente na esfera privada. Como se costuma dizer, Freyre teria descrito a escravidão brasileira, tendo como foco (...) apenas os cativos domésticos. Para tanto, começar-se-á com a análise do clássico Casa Grande & Senzala, mas a insistência se dará na interpretação do livro Novo mundo nos trópicos, obra em que o estudioso procura sintetizar suas conclusões para um público estrangeiro. Aí estariam condensadas as suas máximas e grandes linhas de interpretação.Palavras-chave: Adaptação. Mestiçagem. Novo mundo nos trópicos. Gilberto Freyre. AbstractThe aim of this paper is to produce a critical reflection on Gilberto Freyre’s work, which is more vertical in two respects. First, I will seek to understand the selection made by the anthropologist of a certain cultural miscegenation and adaptation, symbols of Brazilian singularity. Second, I’ll try to understand how such an interpretation shifts the analysis of rather social and economic phenomena, deeply invested in the private. As it is said, Freyre would have described Brazilian slavery focusing only on the domestic slaves. Thus, the analysis begins with the classic Casa Grande & Senzala, but the emphasis will be in the interpretation of the book in the New world in the tropics [Novo mundo nos Trópicos], a work in which the scholar seeks to synthesize his findings to a foreign audience. There it would be condensed his maxima and broad lines of interpretation.Key words: Adaptation. Miscegenation. New world in the tropics. Gilberto Freyre. (shrink)

Cognitive Science, Volume 46, Issue 5, May 2022.

At conceptual and linguistic levels of cognition, events are said to be represented in terms of abstract categories, for example, the sentence Jackie cut the bagel with a knife encodes the categories Agent (i.e., Jackie) and Patient (i.e., the bagel). In this paper, we ask whether entities such as the knife are also represented in terms of such a category (often labeled “Instrument”) and, if so, whether this category has a prototype structure. We hypothesized the Proto-instrument is a tool: a (...) physical object manipulated by an intentional agent to affect a change in another individual or object. To test this, we asked speakers of English, Dutch, and German to complete an event description task and a sentence acceptability judgment task in which events were viewed with more or less prototypical instruments. We found broad similarities in how English, Dutch, and German partition the semantic space of instrumental events, suggesting there is a shared concept of the Instrument category. However, there was no evidence to support the specific hypothesis that tools are the core of the Instrument category—instead, our results suggest the most prototypical Instrument is the direct extension of an intentional agent. This paper supports theoretical frameworks where thematic roles are analyzed in terms of prototypes and suggests new avenues of research on how instrumental category structure differs across linguistic and conceptual domains. (shrink)

This article is the analysis of the content of the Ukrainian periodicals for womenfolk, including the literary-publicistic almanac "Pershyi vinok", the periodical "Meta", the newspaper "Zhinoche dilo" which was a free supplement to the daily social and political narodovskyi publication "Dilo". They were published with the support of the public organizations of Galicia in late 19th and early 20th century and of the activists of the Ukrainian women's movement of the region - Nataliia Kobrynska, Olena Kysilevska, Dariia Starosolska, Iryna Sichynska (...) and others. These periodical and non-periodical publications familiarized Ukrainian women with the best works of Foreign and Ukrainian literature, highlighted the women's movement and the events of political life both in Austria-Hungary and abroad, as well as various aspects of the activities of public organizations where women were involved, published a lot of useful information etc. We believe that the almanac "Pershyi vinok", the newspapers "Meta", "Zhinoche dilo" contributed not only to raising cultural and educational levels of women and spreading among them the ideas of gender equality, but also are valuable sources for the study of the Ukrainian national and cultural movement of Galicia in late 19th and early 20th century. They contain quite a few important facts necessary for a researcher to reconstruct the events of national and cultural life in the region during the above-mentioned period of time. However, a relatively short period of publishing of the said periodicals does not make it possible to get a coherent picture of the Ukrainian women's movement as one of the important components of the national and cultural movement in Galicia in late 19th and early 20th century, thus requiring additional study of both archival and other published sources. (shrink)

One of the most lively debates on scientific understanding is standardly presented as a controversy between the so-called factivists, who argue that understanding implies truth, and the non-factivists whose position is that truth is neither necessary nor sufficient for understanding. A closer look at the debate, however, reveals that the borderline between factivism and non-factivism is not as clear-cut as it looks at first glance. Some of those who claim to be quasi-factivists come suspiciously close to the position of their (...) opponents, the non-factivist, from whom they pretend to differ. The non-factivist, in turn, acknowledges that some sort of ‘answering to the facts’ is indispensable for understanding. This paper discusses an example of convergence of the initially rival positions in the debate on understanding and truth: the use of the same substitute for truth by the quasi-factivist Kareem Khalifa and the non-factivists Henk de Regt and Victor Gijsbers. It is argued that the use of ‘effectiveness’ as a substitute for truth by both parties is not an occasional coincidence of terms, it rather speaks about a deeper similarity which have important implications for understanding the essential features of scientific understanding. (shrink)

In a series of recent publications Jerry Fodor has attacked what many believe is the core of Darwinian theory of evolution – the theory of natural selection. Not surprisingly, Fodor’s attack has provoked a strong negative reaction. Fodor’s critics have insisted both that his main argument is unsound and that his central claim that the theory of natural selection “can’t explain the distribution of phenotypic traits in biological populations” is untenable. I can generally agree with the first part of the (...) launched criticism: Fodor’s “putative argument” does rely on controversial premises which make it unsound. However, I don’t think that Fodor’s critics have succeeded in their attempts to refute his central claim. The refutation strategy that most of them have undertaken is to show examples of successful evolutionary explanations by natural selection. In what follows, two of these examples are put into scrutiny. The analysis reveals that: (1) The theory of natural selection should be only partially credited with the explanatory success of evolutionary explanations by natural selection because these explanations rely on additional empirical hypotheses which might be true or false. That means that the selectionist explanations are fallible statements the truth value of which depends crucially on the truth value of the empirical assumptions which have been premised. (2) In both cases alternative non-selectionist explanations can be found that fit the same empirical data and no reason has been given (or could be given) why these alternative explanations should be ignored a priori as inferior. The observations (1) and (2) stand against the claim that theory of natural selection is the only legitimate explanance for the distribution of phenotypic traits. This does not mean, of course, that natural selection does not play any explanatory role or that the theory of natural selection is a false theory (as Fodor is inclined to argue for). This only means that there is indeed a problem of understanding the proper explanatory role of natural selection and that this problem is not only Fodor’s problem. The paper ends with a suggestion of what should be admitted in order to get to a better understanding of the proper role that the theory of natural selection plays in evolutionary explanations. (shrink)

The central argument in this paper is the following: if we agree that one of the aims of explanation is to provide or increase understanding, and if we assess understanding on the basis of the inferences one can draw from the knowledge of the phenomenon which is understood, then the value of an explanation, i.e. its capacity to provide or increase understanding of the explained phenomenon, should be assessed on the basis of the extra-inferences which this explanation allows for. The (...) extra-inferences which a given explanation allows for constitute its inferential content. The analysis of the explanation’s inferential content could be applied to all kinds of explanations with the aim of assessing their goodness. I show how such an analysis helps us to better understand a number of difficulties that have puzzled contemporary philosophers of explanation: the flagpole counterexample to the deductive-nomological model of explanation, the conjunction problem, the difference between good and bad circular explanations. (shrink)

On observe une nouvelle tendance dans la philosophie des sciences cognitives, manifeste dans les écrits de Betchel et al. qui met en avant l’importance des explications mécanistes au détriment du rôle explicatif des principes. Cet article est un plaidoyer pour rétablir l’équilibre. Il met l’accent sur l’effort d’explication des effets du niveau de base, l’une des plus importantes découvertes empiriques dans l’histoire de la recherche en catégorisation. L’analyse de trois différentes périodes de cette histoire révèle que le recours aux principes (...) y a joué un rôle crucial. Cependant, afin de reconnaître pleinement le rôle explicatif des principes, nous devrions nous préparer à admettre que les explications déductives-nomologiques ne sont pas les seuls types d’explications basées sur des principes. (shrink)

On observe une nouvelle tendance dans la philosophie des sciences cognitives, manifeste dans les écrits de Betchel et al. qui met en avant l’importance des explications mécanistes au détriment du rôle explicatif des principes. Cet article est un plaidoyer pour rétablir l’équilibre. Il met l’accent sur l’effort d’explication des effets du niveau de base, l’une des plus importantes découvertes empiriques dans l’histoire de la recherche en catégorisation. L’analyse de trois différentes périodes de cette histoire révèle que le recours aux principes (...) y a joué un rôle crucial. Cependant, afin de reconnaître pleinement le rôle explicatif des principes, nous devrions nous préparer à admettre que les explications déductives-nomologiques ne sont pas les seuls types d’explications basées sur des principes. (shrink)

This article presents a critical bibliographic review of the central characteristics of Hume's Theory of Passions and Emotions, which conceived the philosophy of human nature as an analytical and experimental science. This view is contrary to the ancient and medieval ideas that passions were movements of the lower parts of the soul. For Hume, passions in general are among the perceptions of the mind, although they also serve as motivations to act and even to reason. The apparent dichotomy that existed (...) between passions and reason was abandoned and reason was treated as a calm passion. Hence, Hume dethroned reason from its sovereign position in knowledge. For him, passions are neither subordinate nor independent of reason; it is the reason that is subordinate to passions. (shrink)

This study empirically tests a sequential mediation model that links ethical leadership with employees’ unethical behaviour. The corruption index for countries is used as the moderator, because it represents both the instrumental ethical climate and the employee displacement of responsibility embedded in society’s ethical standards. A total of 175 participants comprising 41 teams (134 dyads) across 13 countries participated in a dyadic two-wave survey. The findings show that ethical leadership has an indirect influence on the avoidance of unethical behaviour by (...) reducing the instrumental ethical climate and by negating the displacement of individuals’ responsibility. In addition, the results also show that this process is not sensitive to the countries’ corruption levels. Such findings suggest that organizations are less prone to adjust their ethical standards to the environment than is usually expected. Accordingly, ethical leaders of MNCs may be instrumental in counteracting any corruptive pressure in the social environment, and likewise, non-ethical leaders may be a contributing factor to fostering corrupt organizations in a society that otherwise values ethical principles in business. (shrink)

BackgroundBased on an actual case in which a psychiatrist was called in to assess a patient’s capacity to refuse treatment, the aim of this study is to discuss how to manage this ethical and clinical issue and the dilemmas faced by the medical team.Case presentation: The case involved a 45-year-old female patient diagnosed with breast cancer who refused treatment. Since the mastology team had doubts about the patient’s mental state and given that she refused to consent to surgery, a forensic (...) psychiatric consult was requested.ConclusionThe forensic psychiatry team concluded that the patient’s decision-making capacity was preserved. The team suggested some actions to help the specialists deal with the ethical conflict. A reflection is proposed about the role of psychiatrists when an ethical dilemma involving decision-making capacity emerges in clinical situations, elucidating their work not only as physicians who determine diagnoses and conducts, but also as agents of transformation in the doctor–patient re... (shrink)

Os conceitos de espaço e tempo absolutos, independentes entre si, foram propostos por Newton como os mais básicos fundamentos da mecânica clássica. Alguns estudiosos, como Leibniz, admitiram haver alguma interconexão entre o espaço e o tempo. No século passado, devido ao incrível aprimoramento dos instrumentos físicos de observação em diferentes escalas, mudanças aconteceram. Com a relatividade, foi proposto o conceito de espaço-tempo, uma relação linear entre o espaço e o tempo. Com a mecânica quântica, devido a Niels Bohr, as coisas (...) mudaram radicalmente. Na interpretação de Copenhague, os conceitos de espaço e tempo perdem a sua natureza ôntica. Devido à ontologia de Fourier, um postulado implícito da mecânica quântica, qualquer entidade física é assumida como existindo em todo espaço e em todo tempo. Além disso, um fenômeno aparentemente estranho é previsto: o efeito de túnel, que permite (segundo alguns autores) a transmissão de informação em tempo zero. Esses fatos indicam que, possivelmente, os conceitos de espaço e tempo (cronológico), inter-relacionados, talvez não tenham a suposta adequação absoluta e universal, em diferentes escalas de observação e diferentes níveis de descrição da realidade. Neste universo conceptual mais geral, o conceito ôntico mais básico é o Devir, a mudança permanente dos seres físicos. (shrink)

RESPONSABILIDADE ESTATAL NOS CRIMES COMETIDOS CONTRA OS DIREITOS HUMANOS DURANTE A VIGÊNCIA DA DITADURA MILITAR BRASILEIRA.

Transposable elements (TEs) are sequences currently or historically mobile, and are present across all eukaryotic genomes. A growing interest in understanding the regulation and function of TEs has revealed seemingly dichotomous roles for these elements in evolution, development, and disease. On the one hand, many gene regulatory networks owe their organization to the spread of cis‐elements and DNA binding sites through TE mobilization during evolution. On the other hand, the uncontrolled activity of transposons can generate mutations and contribute to disease, (...) including cancer, while their increased expression may also trigger immune pathways that result in inflammation or senescence. Interestingly, TEs have recently been found to have novel essential functions during mammalian development. Here, the function and regulation of TEs are discussed, with a focus on LINE1 in mammals. It is proposed that LINE1 is a beneficial endogenous dual regulator of gene expression and genomic diversity during mammalian development, and that both of these functions may be detrimental if deregulated in disease contexts. (shrink)

In Being and Time, Heidegger presented the finitude of human existence from the concepts of being towards death and anticipatory resoluteness. By interpreting human existence as existential possibility, it becomes possible to properly understand existential death as distinct from death in the vital sense. In view of the projective characteristic of understanding, Heidegger shows that projection into possibilities is always subject to risk and failure, since what sustains the “existential” aspect of existential possibility is projection in it. In this sense, (...) the objective of this article is to present and discuss the concepts of death, existential possibility and finitude existence based on the interpretative thesis that Heidegger’s elaboration of the existential concept of death is independent of the common and mundane sense of death, presented through the concept of demise, based on the thesis proposed by Heidegger that death is the possibility of the impossibility of existence in general. (shrink)